The Peptidic GHS-R Antagonist [D-Lys]GHRP-6 Markedly Improves Adiposity and Related Metabolic Abnormalities in a Mouse Model of Postmenopausal Obesity

L. Maletínská (1) , R. Matyšková (1) , J. Maixnerová (1) , D. Sýkora (2) , M. Pýchová (1) , A. Špolcová (1) , M. Blechová (1) , J. Drápalová (3) , Z. Lacinová (3) , M. Haluzík (3) , B. Železná (1)

1 IOCB / CAS - Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences
2 Institute of Chemical Technology
3 1. LF UK / 1st Faculty of Medicine - 1. lékařská fakulta, Univerzita Karlova [Praha, Česká republika] = First Faculty of Medicine, Charles University [Prague, Czech Republic]

It was demonstrated that estrogen deficiency and consuming high fat (HF) diet enhanced orexigenic activity of ghrelin. Therefore, we hypothesized that antagonizing of ghrelin action would attenuate food intake and body weight in mice obese both from ovariectomy (OVX) and feeding a HF diet.

Mots clés: HF; OVX; PPAR; SC; SPa; St; UCP1; [D-Lys]GHRP-6; [D-Arg; D-Trp; Leu]sub P; ovariectomized obese mice; metabolic syndrome; BAT; DIO; E2; FGF21; GHS-R

Domaines: Biochimie, Biologie Moléculaire

L. Maletínská, R. Matyšková, J. Maixnerová, D. Sýkora, M. Pýchová, et al.. The Peptidic GHS-R Antagonist [D-Lys]GHRP-6 Markedly Improves Adiposity and Related Metabolic Abnormalities in a Mouse Model of Postmenopausal Obesity. Molecular and Cellular Endocrinology, 2011, 343 (1-2), pp.55. ⟨10.1016/j.mce.2011.06.006⟩. ⟨hal-00723608⟩