Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses

Sueleyman Bilal (1, 2) , Oliver Haworth (3) , Lijun Wu , Karsten H. Weylandt (1, 2) , Bruce D. Levy (3) , Jing X. Kang (1)

1 Massachusetts General Hospital [Boston]
2 Department of Gastroenterology
3 Department of Medicine

Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been implicated in the alleviation of asthma. Recent studies have demonstrated that the n-3 PUFA derived lipid mediators, protectin D1 and resolvin E1, may act as potent resolution agonists in airway inflammation. The effects of the n-3 PUFA tissue status itself on asthma pathogenesis remains to be further investigated.

Mots clés: Omega-3; resolvins; protectins; inflammation; asthma; Fat-1 mice

Domaines: Biochimie, Biologie Moléculaire

Sueleyman Bilal, Oliver Haworth, Lijun Wu, Karsten H. Weylandt, Bruce D. Levy, et al.. Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2011, 1812 (9), pp.1164. ⟨10.1016/j.bbadis.2011.05.002⟩. ⟨hal-00719831⟩