Hyaluronan reduces inflammation in experimental arthritis by modulating TLR-2 and TLR-4 cartilage expression

Giuseppe M. Campo (1) , Angela Avenoso (1) , Giancarlo Nastasi (1) , Antonio Micali (2) , Vera Prestipino (1) , Mario Vaccaro (3) , Angela d'Ascola (1) , Alberto Calatroni (1) , Salvatore Campo (1)

1 Department of Biochemical
2 Department of Biomorphology and Biotechnology
3 Policlinico Universitario

Previous studies have reported that low molecular mass HA and highly polymerized HA respectively elicited pro- and anti-inflammatory responses by modulating the toll-like receptor 4 (TLR-4) and the TLR-2. The activation of TLR-4 and TLR-2 mediated by collagen-induced arthritis (CIA) induces the myeloid differentiation primary response protein (MyD88) and the tumor necrosis factor receptor-associated factor 6 (TRAF6), and ends with the liberation of NF-kB which, in turn, stimulates pro-inflammatory cytokine production. The aim of this study was to investigate the influence of high molecular weight HA at different concentrations on TLR-4 and TLR-2 modulation in CIA in mice.

Mots clés: NF-kB; toll-like receptors; cytokines; TNF-alpha; arthritis; hyaluronan

Domaines: Biochimie, Biologie Moléculaire

Giuseppe M. Campo, Angela Avenoso, Giancarlo Nastasi, Antonio Micali, Vera Prestipino, et al.. Hyaluronan reduces inflammation in experimental arthritis by modulating TLR-2 and TLR-4 cartilage expression. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2011, 1812 (9), pp.1170. ⟨10.1016/j.bbadis.2011.06.006⟩. ⟨hal-00719825⟩