MicroRNAs in colorectal cancer: Function, dysregulation and potential as novel biomarkers

M. Nugent (1) , N. Miller (1) , M.J. Kerin (1)

1 NUI Galway - National University of Ireland [Galway]

MicroRNAs (miRNAs) are short non-coding segments of RNA which are involved in normal cellular development and proliferation. Recent studies have identified altered miRNA expression in both tumour tissues and circulation in the presence of colorectal cancer. These altered expression patterns may serve as novel biomarkers for colorectal cancer. This review explores recent developments in this rapidly evolving field.

Mots clés: colorectal; cancer; microRNA; biomarkers

M. Nugent, N. Miller, M.J. Kerin. MicroRNAs in colorectal cancer: Function, dysregulation and potential as novel biomarkers. EJSO - European Journal of Surgical Oncology, 2011, 37 (8), pp.649. ⟨10.1016/j.ejso.2011.05.005⟩. ⟨hal-00715504⟩