Non-susceptibility to tigecycline in enterococci from hospitalised patients, food products and community sources

Ana R. Freitas (1) , Carla Novais (2) , Rosa Correia , Márcia Monteiro , Teresa M. Coque (1) , Luísa Peixe

1 FiBioHRYC - Fundación para la Investigación en Biomédica del Hospital Universitario Ramón y
2 Faculdade Ciências da Saúde

In this study, the in vitro activity of tigecycline against 1140 enterococci collected from humans, food products, animals and the environment in Portugal (1996-2008) was analysed. Ten isolates (seven and three spp.) non-susceptible to tigecycline (minimum inhibitory concentrations of 0.5-1.0mg/L), which were also resistant to tetracycline and minocycline, were mostly observed in samples collected before the introduction of tigecycline in the therapeutic arsenal. The isolates were recovered from hospitalised patients (=2; ST319/CC2 and ST34), healthy humans (=2; ST21/CC21), chicken meat (=1; ST260) as well as from two swine samples. The remaining isolates were also recovered from chicken meat (=1; ) and swine (=2; and spp.). Recovery of enterococcal isolates with reduced susceptibility to tigecycline among different reservoirs, including animals for food consumption, suggests that selection of tigecycline-resistant isolates by antibiotics other than tigecycline might occur in non-clinical settings.

Mots clés: Enterococcus; Hospitals; Healthy humans; Animals; Tigecycline; Tetracycline

Domaines: Microbiologie et Parasitologie

Ana R. Freitas, Carla Novais, Rosa Correia, Márcia Monteiro, Teresa M. Coque, et al.. Non-susceptibility to tigecycline in enterococci from hospitalised patients, food products and community sources. International Journal of Antimicrobial Agents, 2011, ⟨10.1016/j.ijantimicag.2011.04.014⟩. ⟨hal-00711301⟩