MicroRNA-21 and PDCD4 expression in colorectal cancer

K.H Chang (1) , N Miller (1) , E.A.H Kheirelseid (1) , H Ingoldsby (2) , E Hennessy (1) , C.E Curran (1) , S Curran (2) , M.J Smith (1) , M Regan (1) , O.J Mcanena (1) , M.J Kerin (1)

1 Department of Surgery
2 Department of Pathology

MiRNAs regulate gene expression by binding to target sites and initiating translational repression and/or mRNA degradation. Studies have shown that exerts its oncogenic activity by targeting the tumour suppressor 3'-UTR. However, the mechanism of this regulation is poorly understood. In colorectal cancer, loss of has been reported in association with increased tumour aggressiveness and poor prognosis. The purpose of this study was to delineate the interaction between and its oncogenic modulator in colorectal cancer.

Mots clés: Colorectal cancer; PDCD4 tumour suppressor; miRNA-21

K.H Chang, N Miller, E.A.H Kheirelseid, H Ingoldsby, E Hennessy, et al.. MicroRNA-21 and PDCD4 expression in colorectal cancer. EJSO - European Journal of Surgical Oncology, 2011, ⟨10.1016/j.ejso.2011.04.001⟩. ⟨hal-00710923⟩