Tumor necrosis factor alpha-mediated inhibition of erythropoiesis involves GATA-1/GATA-2 balance impairment and PU.1 over-expression

Christine Grigorakaki (1) , Franck Morceau (1) , Sébastien Chateauvieux (1) , Mario Dicato (1) , Marc Diederich (1)

1 Hôpital Kirchberg

Many physiological perturbations can cause anemia. In cancer patients, activation of the immune system leads to the production of proinflammatory cytokines including tumor necrosis factor alpha (TNFα), that have been shown to inhibit red-cell production poorly understood mechanisms. Treatment of anemia by human recombinant erythropoietin EPO) is strongly suspected to induce tumor growth.

Mots clés: anemia; inflammation; TNFα; GATA-1; GATA-2; PU.1

Domaines: Pharmacologie

Christine Grigorakaki, Franck Morceau, Sébastien Chateauvieux, Mario Dicato, Marc Diederich. Tumor necrosis factor alpha-mediated inhibition of erythropoiesis involves GATA-1/GATA-2 balance impairment and PU.1 over-expression. Biochemical Pharmacology, 2011, ⟨10.1016/j.bcp.2011.03.030⟩. ⟨hal-00703551⟩