Ganciclovir treatment in children: Evidence of sub-therapeutic levels

Suzanne Luck (1) , Andrew Lovering (2) , Paul Griffiths (1) , Mike Sharland (3)

1 Division of Infection and Immunity
2 Southmead Hospital
3 Division of Infection

Ganciclovir is used to treat babies and older children with cytomegalovirus-related disease. Treatment courses are generally derived from adult studies and there are few data relating to pharmacokinetics of ganciclovir in children. In adults low trough ganciclovir levels have been associated with treatment failure and virological resistance. Data on suitable drug levels for use in therapeutic drug monitoring in the paediatric age group do not currently exist.

Mots clés: Cytomegalovirus; Children; Ganciclovir; Therapeutic drug monitoring

Domaines: Microbiologie et Parasitologie

Suzanne Luck, Andrew Lovering, Paul Griffiths, Mike Sharland. Ganciclovir treatment in children: Evidence of sub-therapeutic levels. International Journal of Antimicrobial Agents, 2011, 37 (5), pp.445. ⟨10.1016/j.ijantimicag.2010.11.033⟩. ⟨hal-00685797⟩