Antibacterial properties of compounds isolated from

A. Martins (1, 2) , A. Vasas (2) , M. Viveiros (1, 3) , J. Molnár (3, 4) , J. Hohmann (2) , L. Amaral (1, 3)

1 IHMT - Instituto de Higiene e Medicina Tropical
2 Faculty of Pharmacy
3 BM0701 Cost Action (ATENS) of the European Commission/European Science Foundation
4 Faculty of Medicine

Several compounds isolated from the plant were evaluated for their activity against multidrug-resistant (MDR) bacteria and their efflux pump systems Among the compounds isolated, six compounds were tested, namely uvaol, β-amyrin, oleanolic acid, catechin, epicatechin and monogalactosyldiacylglycerol. Oleanolic acid presented high antibacterial activity against a large number of bacterial strains. The triterpene uvaol was the most active compound for modulation of efflux activity by MDR Gram-positive strains.

Mots clés: Carpobrotus edulis; Aizoaceae; Isolated compounds; Staphylococcus aureus; Enterococcus faecalis; Escherichia coli; Salmonella enterica serotype Enteritidis; Mycobacterium tuberculosis; Efflux pumps; Efflux pump inhibition; Multidrug resistance

Domaines: Microbiologie et Parasitologie

A. Martins, A. Vasas, M. Viveiros, J. Molnár, J. Hohmann, et al.. Antibacterial properties of compounds isolated from. International Journal of Antimicrobial Agents, 2011, 37 (5), pp.438. ⟨10.1016/j.ijantimicag.2011.01.016⟩. ⟨hal-00685787⟩