European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment

Veit Roessner (1) , Kerstin J. Plessen (2, 3) , Aribert Rothenberger (4) , Andrea G. Ludolph (5) , Renata Rizzo (6) , Liselotte Skov (7) , Gerd Strand (8) , Jeremy S. Stern (9) , Cristiano Termine (10) , Pieter J. Hoekstra (11)

1 Department of Child and Adolescent Psychiatry
2 Centre for Child and Adolescent Psychiatry at Bispebjerg
3 Department of Neurology, Psychiatry and Sensory Sciences
4 Department of Child and Adolescent Psychiatry
5 Department of Child and Adolescent Psychiatry
6 Renata Rizzo Child and Adolescent Neurology and Psichiatry, Maternal Infantile and Radiological Sciences Department
7 Department of Pediatrics
8 Norwegian Resource Center for AD/HD, Tourette Syndrome and Narcolepsy
9 St George's Hospital Neurology
10 Child Neuropsychiatry Unit, Department of Experimental Medicine
11 Department of Psychiatry

To develop a European guideline on pharmacologic treatment of Tourette syndrome (TS) the available literature was thoroughly screened and extensively discussed by a working group of the European Society for the Study of Tourette syndrome (ESSTS). Although there are many more studies on pharmacotherapy of TS than on behavioral treatment options, only a limited number of studies meets rigorous quality criteria. Therefore, we have devised a two-stage approach. First, we present the highest level of evidence by reporting the findings of existing Cochrane reviews in this field. Subsequently, we provide the first comprehensive overview of all reports on pharmacological treatment options for TS through a MEDLINE, PubMed, and EMBASE search for all studies that document the effect of pharmacological treatment of TS and other tic disorders between 1970 and November 2010. We present a summary of the current consensus on pharmacological treatment options for TS in Europe to guide the clinician in daily practice. This summary is, however, rather a status quo of a clinically helpful but merely low evidence guideline, mainly driven by expert experience and opinion, since rigorous experimental studies are scarce.

Mots clés: Tics; Tourette; Pharmacologic; Treatment; Guidelines

Domaines: Pédiatrie

Veit Roessner, Kerstin J. Plessen, Aribert Rothenberger, Andrea G. Ludolph, Renata Rizzo, et al.. European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment. European Child and Adolescent Psychiatry, 2011, 20 (4), pp.173-196. ⟨10.1007/s00787-011-0163-7⟩. ⟨hal-00683501⟩