Strengthening the reporting of genetic risk prediction studies: the GRIPS statement

A. Cecile J. W. Janssens (1) , John P. A. Ioannidis (2, 3, 4, 5, 6) , Cornelia M. Duijn (1) , Julian Little (7) , Muin J. Khoury (8)

1 Department of Epidemiology
2 Department of Hygiene and Epidemiology
3 Biomedical Research Institute
4 Department of Medicine
5 Center for Genetic Epidemiology and Modeling and Tufts CTSI, Institute for Clinical Research and Health Policy Studies
6 Stanford Prevention Research Center
7 Epidemiology and Community Medicine
8 Office of Public Health Genomics

The rapid and continuing progress in gene discovery for complex diseases is fueling interest in the potential application of genetic risk models for clinical and public health practice. The number of studies assessing the predictive ability is steadily increasing, but the quality and completeness of reporting varies. A multidisciplinary workshop sponsored by the Human Genome Epidemiology Network developed a checklist of 25 items recommended for strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS), building on the principles established by prior reporting guidelines. These recommendations aim to enhance the transparency of study reporting, and thereby to improve the synthesis and application of information from multiple studies that might differ in design, conduct, or analysis. A detailed Explanation and Elaboration document is published.

Mots clés: Genetic; Risk prediction; Methodology; Guidelines; Reporting

Domaines: Santé publique et épidémiologie

A. Cecile J. W. Janssens, John P. A. Ioannidis, Cornelia M. Duijn, Julian Little, Muin J. Khoury. Strengthening the reporting of genetic risk prediction studies: the GRIPS statement. European Journal of Epidemiology, 2011, 26 (4), pp.255-259. ⟨10.1007/s10654-011-9552-y⟩. ⟨hal-00681957⟩