Bis- and Tris-Alkyne Phosphoramidites for Multiple 5'-Labelling of Oligonucléotides by click Chemistry

Caroline Ligeour (1) , Albert Meyer (1) , Jean-Jacques Vasseur (1) , François Morvan (1)

1 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]

Three new phosphoramidites exhibiting two or three alkyne functions were prepared and introduced at the 5

Mots clés: Oligonucleotides; Nucleic acids; Conjugation; Carbohydrates; Alkynes; Click chemistry

Domaines: Chimie organique

Caroline Ligeour, Albert Meyer, Jean-Jacques Vasseur, François Morvan. Bis- and Tris-Alkyne Phosphoramidites for Multiple 5'-Labelling of Oligonucléotides by click Chemistry. European Journal of Organic Chemistry, 2012, pp.1851-1856. ⟨10.1002/ejoc.201101763⟩. ⟨hal-00679210⟩