CRTH2 and CD161 define a human IL-­25 and IL-33−responsive type 2 innate lymphoid cell type

Hergen Spits (1) , Jenny Marie Mjosberg (1) , Sara Trifari (1) , Natasha Crellin (1) , Charlotte P Peters (1) , Cornelis M van Drunen (1) , Berber Piet (1) , Wytske J Fokkens (1) , Tom Cupedo (1)

1 Tytgat Institute for Liver and Intestinal Research

Innate lymphoid cells (ILCs) are emerging as a family of effectors and regulators of innate immunity and tissue remodeling. Interleukin 22 (IL-22) and IL-17−producing ILCs, which depend on RORγt, express CD127 and CD161. We describe another Lin− CD127+CD161+ ILC population found in humans that express the chemoattractant receptor CRTH2. These cells responded in vitro to IL-2 plus IL-25 and IL-33 by producing IL-13. CRTH2+ ILCs were found in fetal and adult lung and gut. In fetal gut these cells expressed IL-13 but not IL-17 or IL-22. CRTH2+ ILCs were enriched in nasal polyps of chronic rhinosinusitis, a typical type 2 inflammatory disease. These data identify a unique human ILC type, which provides an innate source of TH2 cytokines.

Mots clés: Innate immunity; Allergy; Mucosal immunology; Cytokines

Domaines: Immunologie

Hergen Spits, Jenny Marie Mjosberg, Sara Trifari, Natasha Crellin, Charlotte P Peters, et al.. CRTH2 and CD161 define a human IL-­25 and IL-33−responsive type 2 innate lymphoid cell type. Nature Immunology, 2011, ⟨10.1038/ni.2104⟩. ⟨hal-00677959⟩