Metal-free Michael addition initiated multicomponent oxidative cyclodehydration route to polysubstituted pyridines from 1,3-dicarbonyls

Frédéric Liéby-Müller (1) , Christophe Allais (1) , Thierry Constantieux (2) , Jean Rodriguez (1)

1 STeRéO
2 ISM2 - Institut des Sciences Moléculaires de Marseille

A simple metal-free, step-economic and selective access to pyr- idines from readily available substrates is reported, involving a flexible4A ̊ molecularsievespromotedMichaeladditioninitiated domino three-component reaction between a 1,3-dicarbonyl, a Michael acceptor and a synthetic equivalent of ammonia.

Mots clés: Pyridines; multicomponent reaction; Michael addition; 3-dicarbonyl

Domaines: Chimie organique

Frédéric Liéby-Müller, Christophe Allais, Thierry Constantieux, Jean Rodriguez. Metal-free Michael addition initiated multicomponent oxidative cyclodehydration route to polysubstituted pyridines from 1,3-dicarbonyls. Chemical Communications, 2008, pp.4207-4209. ⟨10.1039/b805680c⟩. ⟨hal-00677037⟩