Liquorice and glycyrrhetinic acid increase DHEA and deoxycorticosterone levels by inhibiting adrenal SULT2A1 activity

E.A.S. Al-Dujaili (1) , C.J. Kenyon (2) , M.R. Nicol (2) , J.I. Mason (2)

1 Department of Dietetics
2 Edin. - University of Edinburgh

The mineralocorticoid effects of liquorice are mediated by the inhibitory effects of one of its active components glycyrrhetinic acid on 11β-hydroxysteroid dehydrogenase type 2. However, liquorice is reputed to have many medicinal properties and also contains a number of other potentially biologically active compounds. Here we have investigated the wider effects of oral liquorice on steroidogenesis focussing particularly on possible inhibitory effects of glycyrrhetinic acid on adrenal sulfotransferase activity.

Mots clés: 11HSD; DOC; DHEA; ELISA; GA; SULT2A1; RAAS; Deoxycorticosterone; Liquorice; Glycyrrhetinic acid

Domaines: Biochimie, Biologie Moléculaire

E.A.S. Al-Dujaili, C.J. Kenyon, M.R. Nicol, J.I. Mason. Liquorice and glycyrrhetinic acid increase DHEA and deoxycorticosterone levels by inhibiting adrenal SULT2A1 activity. Molecular and Cellular Endocrinology, 2011, 336 (1-2), pp.102. ⟨10.1016/j.mce.2010.12.011⟩. ⟨hal-00675792⟩