Pathophysiological idiosyncrasies and pharmacokinetic realities may interfere with tacrolimus dose titration in liver transplantation

Itziar Oteo (1) , John C. Lukas (1, 2) , Nerea Leal (2) , Elena Suarez (1) , Andres Valdivieso (3, 4) , Mikel Gastaca (3) , Jorge Ortiz Urbina (3) , Rosario Calvo (1)

1 Department of Pharmacology, School of Medicine
2 Drug Modeling & Consulting
3 Liver Transplantation Unit
4 Department of Surgery, School of Medicine

Mots clés: Tacrolimus; Liver transplantation; Monitoring; Pharmacokinetic assumptions; Idiosyncrasy

Domaines: Pharmacologie

Itziar Oteo, John C. Lukas, Nerea Leal, Elena Suarez, Andres Valdivieso, et al.. Pathophysiological idiosyncrasies and pharmacokinetic realities may interfere with tacrolimus dose titration in liver transplantation. European Journal of Clinical Pharmacology, 2011, 67 (7), pp.671-679. ⟨10.1007/s00228-011-0998-3⟩. ⟨hal-00671235⟩