FACTORS INFLUENCING REPRODUCIBILITY OF TUMOUR REGRESSION GRADING AFTER HIGH DOSE CHEMORADIATION OF LOCALLY ADVANCED RECTAL CANCER

Jan Lindebjerg (1) , Niels Hansborg (2) , John Ploen (3) , Soren Rafaelsen (4) , Jens Christian Riis Jorgensen (5) , Anders Jakobsen (3)

1 Dpt. of Clinical Pathology
2 Dpt. of Clinical Pathology
3 Dpt. of Oncology
4 Dpt. of Radiology
5 Dpt. of Surgery

High dose chemoradiation is now considered standard treatment of locally advanced rectal cancer. To provide feedback on the effect of this treatment, several regression grading systems have been proposed. For a grading system to be useful it has to be reproducible. The aim of this study was to test the reproducibility of a five point grading system, originally proposed by Mandard, and to describe the sources of disagreement. Tumor regression was assessed independently by two observers on 100 consecutive chemo radiated rectal cancer specimens. The grading system was very reproducible with weighted and unweighted kappa values of 0,89 and 0,82 respectively. The most frequent source of disagreement was assessment of the relative amount of fibrosis. Displacement of epithelium was a minor source.

Mots clés: Medicine

Jan Lindebjerg, Niels Hansborg, John Ploen, Soren Rafaelsen, Jens Christian Riis Jorgensen, et al.. FACTORS INFLUENCING REPRODUCIBILITY OF TUMOUR REGRESSION GRADING AFTER HIGH DOSE CHEMORADIATION OF LOCALLY ADVANCED RECTAL CANCER. Histopathology, 2011, 59 (1), pp.18. ⟨10.1111/j.1365-2559.2011.03888.x⟩. ⟨hal-00661256⟩