Modulation of Bcl-2-related protein expression in pancreatic beta cells by pro-inflammatory cytokines and its dependence on the antioxidative defense status

Ilir Mehmeti (1) , Sigurd Lenzen (1) , Stephan Lortz (1)

1 MHH - Medizinische Hochschule Hannover = Hannover Medical School

Pro-inflammatory cytokines are key mediators in the selective and progressive destruction of insulin-producing beta cells during type 1 diabetes development. However, the mechanisms of cytokine-induced beta cell apoptosis are not fully understood.

Mots clés: Bcl-2 proteins; pancreatic beta cells; antioxidative defense status; pro-inflammatory cytokines; apoptosis

Ilir Mehmeti, Sigurd Lenzen, Stephan Lortz. Modulation of Bcl-2-related protein expression in pancreatic beta cells by pro-inflammatory cytokines and its dependence on the antioxidative defense status. Molecular and Cellular Endocrinology, 2010, 332 (1-2), pp.88. ⟨10.1016/j.mce.2010.09.017⟩. ⟨hal-00654967⟩