Melanocortin receptors and their accessory proteins

Sadani N. Cooray (1) , Adrian J.L. Clark (1)

1 William Harvey Research Institute, Barts and the London Medical School

The melanocortin receptor family consists of 5 members which belong to the GPCR superfamily. Their specific ligands, the melanocortins are peptide hormones which are formed by the proteolytic cleavage of the proopiomelanocortin (POMC) protein. It is now recognised that certain GPCRs require accessory proteins for their function. Like these GPCRs the melanocortin receptor family is also known to be associated with accessory proteins that regulate their function.

Mots clés: MC1R; MC2R; MC3R; MC4R; MC5R; MRAP; MRAP2

Sadani N. Cooray, Adrian J.L. Clark. Melanocortin receptors and their accessory proteins. Molecular and Cellular Endocrinology, 2010, 331 (2), pp.215. ⟨10.1016/j.mce.2010.07.015⟩. ⟨hal-00654482⟩