Treatment of murine infection with liposomal amphotericin B plus terbinafine

Mery Ruíz-Cendoya (1) , F. Javier Pastor (1) , Javier Capilla (1) , Josep Guarro (1)

1 Facultat de Medicina i Ciències de la Salut

Using a murine model of disseminated infection by , the efficacy of liposomal amphotericin (L-AmB) B at 10mg/kg body weight once daily and terbinafine (TRB) at 150mg/kg body weight twice daily, alone and in combination, was evaluated. The combination of L-AmB with TRB was the only treatment able to prolong survival and to reduce fungal loads in the spleen and kidneys of mice infected with either strain of used. The results suggest that this combination may have a role in the treatment of infection.

Mots clés: Liposomal amphotericin B; Terbinafine

Mery Ruíz-Cendoya, F. Javier Pastor, Javier Capilla, Josep Guarro. Treatment of murine infection with liposomal amphotericin B plus terbinafine. International Journal of Antimicrobial Agents, 2010, 37 (1), pp.58. ⟨10.1016/j.ijantimicag.2010.08.008⟩. ⟨hal-00651641⟩