Flip-flop kinetics of ropivacaine during continuous epidural infusion influences its accumulation rate

Maria Cusato (1) , Massimo Allegri (2) , Tekla Niebel (2, 3) , Pablo Ingelmo (4) , Monica Broglia (1) , Antonio Braschi (2, 5) , Mario Regazzi (1)

1 Laboratory of Clinical Pharmacokinetics
2 Department of Anesthesia and Intensive Care I and Pain Therapy
3 Department of Surgical Science
4 First Service of Anesthesia and Intensive Care, San Gerardo Hospital Monza (MI) - Department of Experimental Medicine
5 Department of Resuscitation and Organ Transplantation Surgery Sciences, Section of Anesthesiology and Resuscitation

Mots clés: Ropivacaine; Flip-flop kinetics; Pharmacokinetics; Drug accumulation; Drug exposure

Maria Cusato, Massimo Allegri, Tekla Niebel, Pablo Ingelmo, Monica Broglia, et al.. Flip-flop kinetics of ropivacaine during continuous epidural infusion influences its accumulation rate. European Journal of Clinical Pharmacology, 2010, 67 (4), pp.399-406. ⟨10.1007/s00228-010-0927-x⟩. ⟨hal-00642397⟩