Renal aging in WKY rats: Changes in Na,K-ATPase function and oxidative stress

E. J. Silva , V. Pinto , S. Simão , M.P. Serrão , J. Afonso , J. Amaral , M.J. Pinho , P. Gomes , P. Soares-Da-Silva

It has been suggested that alterations in Na,K-ATPase mediate the development of several aging-related pathologies, such as hypertension and diabetes. Thus, we evaluated Na,K-ATPase function and HO production in the renal cortex and medulla of Wistar Kyoto (WKY) rats at 13, 52 and 91 weeks of age. Creatinine clearance, proteinuria, urinary excretion of Na and K and fractional excretion of Na were also determined.

Mots clés: WKY; HO; FeNa; GFR; Aging; Na; K-ATPase; Renal cortex; Renal Medulla; Hydrogen Peroxide

E. J. Silva, V. Pinto, S. Simão, M.P. Serrão, J. Afonso, et al.. Renal aging in WKY rats: Changes in Na,K-ATPase function and oxidative stress. Experimental Gerontology, 2010, 45 (12), pp.977. ⟨10.1016/j.exger.2010.09.012⟩. ⟨hal-00641498⟩