Impact of acoustic airflow nebulization on intrasinus drug deposition of a human plastinated nasal cast: New insights into the mechanisms involved

Marc Durand (1) , Jérémie Pourchez (2, 3, 4) , Gérald Aubert (5) , Sandrine Le Guellec (6, 7) , Laurent Navarro (3, 4, 8) , Valérie Forest (2, 3, 4) , Philippe Rusch (9) , Michèle Cottier (10, 11)

1 Oto-Rhino-Laryngologie
2 LINA-ENSME - Laboratoire Interdisciplinaire des Nanoparticules Aérosolisées
3 IFRESIS - Institut Fédératif de Recherche en Sciences et Ingénierie de la Santé
4 CIS-ENSMSE - Centre Ingénierie et Santé
5 Laboratoire Antibiologie
6 PRPA - Pathologies Respiratoires : Protéolyse et Aérosolthérapie
7 DTF-Aerodrug
8 DB2M-ENSMSE - Département Biomécanique et Biomatériaux
9 Oto-Rhino-Laryngologie
10 LINA-ENSMSE - Laboratoire Interdisciplinaire d'Etude des Nanoparticules Aérosolisées
11 Service d'Histologie Embryologie

The impact of 100 Hz (Hertz) acoustic frequency airflow on sinus drug deposition of aerosols was investigated using a human plastinated nasal cast. The influence of drug concentration and endonasal anatomical features on the sinus deposition enhanced by the 100 Hz acoustic airflow was also examined. Plastinated models were anatomically, geometrically and aerodynamically validated (endoscopy, CT scans, acoustic rhinometry and rhinomanometry). Using the gentamicin as a marker, 286 experiments of aerosol deposition were performed. Changes of airborne particles metrology produced under different nebulization conditions (100 Hz acoustic airflow and gentamicin concentration) were also examined. Aerodynamic and geometric investigations highlighted a global behaviour of plastinated models in perfect accordance with a nasal decongested healthy subject. The results of intrasinus drug deposition clearly demonstrated that the aerosols can penetrate into the maxillary sinuses. The 100 Hz acoustic airflow led to increase the deposition of drug into the maxillary sinuses by a factor 2-3 depending on the nebulization conditions. A differential intrasinus deposition of active substance depending on maxillary ostium anatomical features and drug concentration was emphasized. The existence of a specific transport mechanism of penetration of nebulized particles delivered with acoustic airflow was proposed.

Mots clés: Acoustic airflow; Aerosol therapy; Drug deposition; Plastination; Maxillary sinus

Domaines: Génie des procédés; Ingénierie biomédicale

Marc Durand, Jérémie Pourchez, Gérald Aubert, Sandrine Le Guellec, Laurent Navarro, et al.. Impact of acoustic airflow nebulization on intrasinus drug deposition of a human plastinated nasal cast: New insights into the mechanisms involved. International Journal of Pharmacy, 2011, 421 (1), pp.63-71. ⟨10.1016/j.ijpharm.2011.09.023⟩. ⟨hal-00640705⟩