OSTEOPROTEGERIN INJECTION INDUCES MORPHOLOGICAL AND FUNCTIONAL ALTERATIONS IN MOUSE PANCREATIC ISLETS

Barbara Toffoli (1) , Stella Bernardi (2) , Riccardo Candido (3) , Nicoletta Sabato (2) , Renzo Carretta (2) , Federica Corallini (1) , Paola Secchiero (1) , Giorgio Zauli (4) , Bruno Fabris (2)

1 Department of Morphology and Embriology
2 Department of Medical
3 Diabetic Center
4 Institute for Maternal and Child Health

Although serum osteoprotegerin (OPG) is significantly increased in diabetic subjects, its potential role in beta cell dysfunction has not been investigated. This study aimed to assess the effect of full length OPG administered in mice on pancreatic islet structure and function and its interaction with the renin-angiotensin system (RAS).

Mots clés: angiotensin converting enzyme inhibitor; Osteoprotegerin; diabetes; renin-angiotensin system; angiotensin converting enzyme inhibitor.

Barbara Toffoli, Stella Bernardi, Riccardo Candido, Nicoletta Sabato, Renzo Carretta, et al.. OSTEOPROTEGERIN INJECTION INDUCES MORPHOLOGICAL AND FUNCTIONAL ALTERATIONS IN MOUSE PANCREATIC ISLETS. Molecular and Cellular Endocrinology, 2010, 331 (1), pp.136. ⟨10.1016/j.mce.2010.08.019⟩. ⟨hal-00639765⟩