A spatial model of cellular molecular trafficking including active transport along microtubules

A. Cangiani (1) , R. Natalini (2)

1 Dipartimento di Matematica e Applicazioni
2 Consiglio Nazionale delle Ricerche c/o Department of Mathematics

We consider models of Ran-driven nuclear transport of molecules such as proteins in living cells. The mathematical model presented is the first to take into account for the active transport of molecules along the cytoplasmic microtubules. All parameters entering the models are thoroughly discussed. The model is tested by numerical simulations based on Discontinuous Galerkin finite element methods. The numerical experiments are compared to the behavior observed experimentally.

Mots clés: Signal transduction; Intracellular transport; Protein motors; Microtubules; Discontinuous Galerkin Methods

A. Cangiani, R. Natalini. A spatial model of cellular molecular trafficking including active transport along microtubules. Journal of Theoretical Biology, 2010, 267 (4), pp.614. ⟨10.1016/j.jtbi.2010.08.017⟩. ⟨hal-00637805⟩