SEVERE INFUSION REACTIONS TO INFLIXIMAB: ETIOLOGY, IMMUNOGENICITY, AND RISK FACTORS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

Casper Steenholdt (1) , Morten Svenson (2) , Klaus Bendtzen (2, 3) , Ole Østergaard Thomsen (4) , Jørn Brynskov (4) , Mark Andrew Ainsworth (4)

1 Dept of Gastroenterology
2 Biomonitor A/S
3 Institute for Inflammation Research
4 Dept of Gastroenterology

Background: Infliximab (IFX) elicits acute severe infusion reactions in about 5% of patients with inflammatory bowel disease (IBD). Aim: To investigate the role of anti-IFX antibodies (Ab) and other risk factors. Methods: The study included all IBD patients treated with IFX at a Danish university hospital until 2010 either continuously (IFX every 4-12 weeks) or episodically (reinitiation after >12 weeks). Anti-IFX Ab were measured by radioimmunoassay. Results: Twenty-five (8%) of 315 patients experienced acute severe infusion reactions. Univariate analysis showed that patients who reacted were younger at the time of diagnosis (19 vs 26 years, p=0.013) and at first IFX infusion (28 vs 35 years, p=0.012). Furthermore, they more often received episodic therapy (72 vs 31%, p<0.001), and logistic regression revealed this as the only significant predictor of reactions (OR 5 [2-13]; p<0.001). IFX reinitiation after 6 months intermission further increased the risk (OR 8 [3-20], p<0.001). Most reactions (n=14, 88%) occurred at 2nd infusion in the 2nd treatment series (p=0.006). Anti-IFX IgG Ab were highly positive in 19 of 20 patients (95%) shortly after the reactions (median 84 U/ml). Anti-IFX IgG Ab measured prior to the retreatment series were negative in 7 of 11 patients tested (64%). Anti-IFX IgE Ab were negative in all patients with reactions. Conclusion: Acute severe infusion reactions were strongly associated with development of anti-IFX IgG Ab, but not with anti-IFX IgE Ab. The risk was particularly high at the 2nd infusion in retreatment series. Negative anti-IFX Ab before reinitiation did not rule out reactions.

Mots clés: Medicine

Casper Steenholdt, Morten Svenson, Klaus Bendtzen, Ole Østergaard Thomsen, Jørn Brynskov, et al.. SEVERE INFUSION REACTIONS TO INFLIXIMAB: ETIOLOGY, IMMUNOGENICITY, AND RISK FACTORS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE. Alimentary Pharmacology and Therapeutics, 2011, 34 (1), pp.51. ⟨10.1111/j.1365-2036.2011.04682.x⟩. ⟨hal-00637801⟩