Increasing health burden associated with Clostridium difficile diarrhoea in patients with inflammatory bowel disease.

Min-Hua Jen (1) , Sonia Saxena (1) , Alex Bottle (1) , Paul Aylin (1) , Richard Pollok (2)

1 Primary care and public health
2 St George's Hospital NHS Healthcare Trust

Background Clostridium difficile (C. difficile) infection in hospitals in developed countries continues to be a major public health hazard despite increased control measures including review of antibiotic policies and hygiene measures. Patients with colitis are thought to be particularly vulnerable to C. difficile associated diarrhoea (CDAD). Identifying the clinical burden among hospitalised patients admitted with inflammatory bowel disease (IBD) is an essential first step towards identifying and treating severe C. difficile infection in such individuals. Aim To determine excess morbidity and in-hospital mortality associated with hospital acquired C. difficile associated diarrhoea in patients with inflammatory bowel disease (IBD-CDAD-HAI) admitted to NHS hospitals in England compared with those admitted for IBD alone Methods Time trends study of all admissions to NHS hospitals between 2002/03 and 2007/08. We developed case definitions for IBD-CDAD-HAI patients. The primary outcomes were in-hospital mortality and length of stay. The secondary outcome was gastrointestinal surgery. Results Patients in the IBD-CDAD-HAI group were more likely to die in hospital (adjusted OR 6.32), had 28.3 days longer in-patient stays and higher GI surgery rates (adjusted OR 1.87) than patients admitted for IBD alone. Conclusions Patients with IBD admitted to NHS hospitals in England with co-existent C. difficile infection are at risk of greater in-hospital mortality and morbidity than patients admitted for IBD alone

Mots clés: Medicine

Min-Hua Jen, Sonia Saxena, Alex Bottle, Paul Aylin, Richard Pollok. Increasing health burden associated with Clostridium difficile diarrhoea in patients with inflammatory bowel disease.. Alimentary Pharmacology and Therapeutics, 2011, 33 (12), pp.1322. ⟨10.1111/j.1365-2036.2011.04661.x⟩. ⟨hal-00634811⟩