Development of Type I Gastric Carcinoid in patients with Chronic atrophic gastritis

Lucy Vannella , Andrea Sbrozzi-Vanni , Edith Lahner , Cesare Bordi , Emanuela Pilozzi , Vito Domenico Corleto , John Frederick Osborn (1) , Gianfranco Delle Fave , Bruno None Annibale (2)

1 Public Health Science
2 Clinical Science

Background: Long-term observational studies assessing the incidence of Type I Gastric Carcinoid (GC) in patients with chronic atrophic gastritis are few. The aim of the present study was to evaluate the occurrence at diagnosis and during follow-up and to identify patient features associated with the presence of TypeIGC in a cohort of chronic atrophic gastritis patients. Methods: 367 chronic atrophic gastritis patients (245 females, age 54[18-79]years) underwent regular follow-up by gastroscopy. The incidence of TypeIGC was determined in chronic atrophic gastritis patients with at least 2 years of follow-up (n=214). Baseline clinical and histological features were analysed as factors associated with the presence of TypeIGC by univariate analysis. Results: TypeIGC was diagnosed in 9(2.4%) patients at the moment when chronic atrophic gastritis was diagnosed. After 1463 person-years, 6 patients developed TypeIGC with an annual incidence rate (person-year) of 0.4 %. Patients with TypeIGC had significantly higher levels of gastrin, chromogranin A and more frequently the presence of body polyps and ECL-dysplasia compared with chronic atrophic gastritis patients without TypeIGC. Conclusion: This cohort study shows that TypeIGC is a rare complication in patients with chronic atrophic gastritis and the presence of body polyps and ECL-dysplasia at gastroscopic/histologic evaluation are strongly associated with the presence of TypeIGC.

Mots clés: Medicine

Lucy Vannella, Andrea Sbrozzi-Vanni, Edith Lahner, Cesare Bordi, Emanuela Pilozzi, et al.. Development of Type I Gastric Carcinoid in patients with Chronic atrophic gastritis. Alimentary Pharmacology and Therapeutics, 2011, 33 (12), pp.1361. ⟨10.1111/j.1365-2036.2011.04659.x⟩. ⟨hal-00632733⟩