Local imipenem activity against decreases in vivo in the presence of siliconized latex

C. Pichardo (1) , M. C. Conejo (2) , F. Docobo-Pérez (1) , C. Velasco (2) , R. López-Rojas (1) , I. García (2) , M. E. Pachón-Ibáñez (1) , J. M. Rodríguez (2) , J. Pachón (1) , A. Pascual (2)

1 Infectious Diseases Service, Instituto de Biomedicina de Sevilla
2 Department of Microbiology

Zinc eluted from siliconized latex (SL) increases resistance of to imipenem in vitro. A foreign body peritonitis model was used to evaluate the activity of imipenem using SL or silicone (S) implants. No differences were observed in mortality, positive blood cultures and tissue bacterial counts between SL and S implants. Implant-associated counts, however, were significantly higher in the SL group. It is concluded that SL decreases the activity of imipenem against .

Mots clés: Zinc; Latex; Experimental foreign body peritonitis model

C. Pichardo, M. C. Conejo, F. Docobo-Pérez, C. Velasco, R. López-Rojas, et al.. Local imipenem activity against decreases in vivo in the presence of siliconized latex. European Journal of Clinical Microbiology and Infectious Diseases, 2010, 30 (2), pp.289-291. ⟨10.1007/s10096-010-1084-y⟩. ⟨hal-00630414⟩