High-performance liquid chromatographic method for the determination of sorafenib in human serum and peritoneal fluid

Werner J. Heinz (1) , Kathrin Kahle (1) , Annegret Helle-Beyersdorf (1) , Diana Schirmer (1) , Ulrike Lenker (1) , Daniela Keller (1) , Peter Langmann (1) , Hartwig Klinker (1)

1 Department of Internal Medicine II

Mots clés: Sorafenib; Hepatocellular carcinoma; HPLC; Validation; Serum concentrations; Peritoneal fluid

Werner J. Heinz, Kathrin Kahle, Annegret Helle-Beyersdorf, Diana Schirmer, Ulrike Lenker, et al.. High-performance liquid chromatographic method for the determination of sorafenib in human serum and peritoneal fluid. Cancer Chemotherapy and Pharmacology, 2010, 68 (1), pp.239-245. ⟨10.1007/s00280-010-1474-y⟩. ⟨hal-00629967⟩