Somatic DNA alterations in lung epithelial barrier cells in COPD patients

Katerina D. Samara , Eleni G. Tzortzaki , Eirini Neofytou , Alexandros D. Karatzanis , Irini Lambiri , Nikolaos Tzanakis , Nikolaos M. Siafakas

Instability of the Microsatellite DNA (MSI) and Loss of Heterozygosity (LOH) have been previously detected in sputum cells of COPD patients. However, the particular cell subpopulation exhibiting genetic instability in COPD was uncertain. The aim of this study was to determine which cell type expresses Microsatellite DNA Instability in sputum and BALF samples from COPD patients.

Mots clés: lung epithelial barrier cells; chronic obstructive pulmonary disease; microsatellite instability; loss of heterozygosity; somatic DNA alterations

Katerina D. Samara, Eleni G. Tzortzaki, Eirini Neofytou, Alexandros D. Karatzanis, Irini Lambiri, et al.. Somatic DNA alterations in lung epithelial barrier cells in COPD patients. Pulmonary Pharmacology & Therapeutics, 2010, 23 (3), pp.208. ⟨10.1016/j.pupt.2009.12.001⟩. ⟨hal-00628367⟩