Immediate reconstruction with implants in women with invasive breast cancer does not affect oncological safety in a matched cohort study

C. Eriksen (1, 2) , J. Frisell (1) , M. Wickman (1, 3) , E. Lidbrink (4) , K. Krawiec (5) , K. Sandelin (1)

1 Department of Molecular Medicine and Surgery
2 Department of Breast and Endocrine Surgery
3 Department of Reconstructive and Plastic Surgery
4 Department of Oncology-Pathology
5 Oncologic Centre

Physicians are still concerned about the oncological safety regarding immediate breast reconstruction (IBR) in breast cancer patients. This study aimed to evaluate possible differences between local, regional, and distant recurrences between women having implant-based reconstruction versus women operated with mastectomy alone. Secondary aims were to evaluate time to oncological treatment as well as disease-free and breast-cancer-specific survival. In a retrospective cohort designed study, 300 reconstructed patients with invasive breast cancer were matched with 300 patients from the population-based Regional Breast Cancer Register of the Stockholm-Gotland health-care region operated with mastectomy alone. They were matched for age, tumor size, nodal stage, and year of operation. Also included were patients treated with neoadjuvant chemotherapy and postoperative radiotherapy. The median follow-up for both the groups was 11.5 years (range 2-20). There were no significant differences in the local recurrence rate, 8.2% in the IBR group and 9.0% in the control group or in the regional recurrence rate, 8.2% versus 9.7%. Distant metastases occurred more frequently in the control group (27.1%) when compared to the IBR group (20.3%). There were no significant differences in time to treatment or in complications rate. Breast cancer mortality was 17% for the IBR group and 23% in the control group during follow-up. This long-term follow-up survey with a well-matched control group demonstrates that IBR with implants is safe to offer patients with invasive breast cancer without any negative effect on the oncological safety.

Mots clés: Breast cancer; Immediate breast reconstruction; Recurrence rate; Oncological safety; Delay adjuvant treatment; Radiotherapy

C. Eriksen, J. Frisell, M. Wickman, E. Lidbrink, K. Krawiec, et al.. Immediate reconstruction with implants in women with invasive breast cancer does not affect oncological safety in a matched cohort study. Breast Cancer Research and Treatment, 2011, 127 (2), pp.439-446. ⟨10.1007/s10549-011-1437-y⟩. ⟨hal-00624173⟩