Upregulation of Stromal cell derived factor-1α in Collagen Vascular Diseases - associated interstitial pneumonias (CVDs-IPs)

Giorgos A. Margaritopoulos , Katerina M. Antoniou , Giannoula Soufla , Konstantinos Karagiannis , Athanasia Proklou , Ismini Lasithiotaki , Nikolaos Tzanakis , Demetrios A. Spandidos , Nikolaos M. Siafakas

We speculated that distinct angiogenic profiles are involved in idiopathic interstitial pneumonias (IIPs) in comparison with interstitial pneumonias associated with collagen vascular disease (CVD-IPs). This hypothesis was investigated by measuring the expression of a cardinal biologic axis, the vascular endothelial growth factor (VEGF) -stromal derived growth factor [SDF-1α, transcripts 1 and 2 (TR1 and TR2)] and receptor, CXCR4 and the angiogenetic receptors CXCR2 and CXCR3 in bronchoalveolar lavage fluid (BALF) in both conditions.

Mots clés: angiogenesis; connective tissue disorders; interstitial pneumonias; chemokines; pulmonary fibrosis

Giorgos A. Margaritopoulos, Katerina M. Antoniou, Giannoula Soufla, Konstantinos Karagiannis, Athanasia Proklou, et al.. Upregulation of Stromal cell derived factor-1α in Collagen Vascular Diseases - associated interstitial pneumonias (CVDs-IPs). Pulmonary Pharmacology & Therapeutics, 2010, 23 (2), pp.115. ⟨10.1016/j.pupt.2009.10.008⟩. ⟨hal-00614331⟩