Parvalbumin-positive CA1 interneurons are required for spatial working but not reference memory

Andrew J. Murray (1) , Jonas- Frederic Sauer (1) , Gernot Riedel (1) , Christina Mcclure (1) , Laura Ansel (1) , Lesley Cheyne (1) , Marlene Bartos (1) , William Wisden (1) , Peer Wulff (1)

1 Institute of Medical Sciences

Parvalbumin-positive (PV) GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly we functionally removed PV interneurons selectively from hippocampal CA1 in mice. We found that PV interneurons are dispensable for spatial reference but essential for spatial working memory.

Mots clés: Memory; Behaviour; Psychiatric Disorders; Synaptic Transmission

Andrew J. Murray, Jonas- Frederic Sauer, Gernot Riedel, Christina Mcclure, Laura Ansel, et al.. Parvalbumin-positive CA1 interneurons are required for spatial working but not reference memory. Nature Neuroscience, 2011, ⟨10.1038/nn.2751⟩. ⟨hal-00612704⟩