Vasoconstriction after inhalation of budesonide: a study in the isolated and perfused rat lung

Pär Ewing , Åke Ryrfeldt , Carl-Olof Sjöberg , Paul Andersson , Staffan Edsbäcker , Per Gerde

Clinical studies have shown that inhaled corticosteroids can induce rapid vasoconstriction in the airways, leading to decreased mucosal blood flow. The aim of this study was to investigate whether vasoconstriction of the pulmonary circulation after short inhalation of a corticosteroid can be detected in the isolated and perfused rat lung (IPL) - a model which could serve as a substitute or a complement to clinical models.

Mots clés: corticosteroids; budesonide; nongenomic; pulmonary circulation; vasoconstriction

Pär Ewing, Åke Ryrfeldt, Carl-Olof Sjöberg, Paul Andersson, Staffan Edsbäcker, et al.. Vasoconstriction after inhalation of budesonide: a study in the isolated and perfused rat lung. Pulmonary Pharmacology & Therapeutics, 2010, 23 (1), pp.9. ⟨10.1016/j.pupt.2009.09.004⟩. ⟨hal-00610670⟩