Presence of plasmid-mediated quinolone resistance in isolates possessing in Greece

I. Galani (1) , M. Souli (1) , N. Mitchell (1) , Z. Chryssouli (1) , H. Giamarellou (1)

1 Molecular Biology Section

Among nalidixic acid-resistant, ciprofloxacin-susceptible and clinical isolates recovered over a 5-month period from inpatients and outpatients of Attikon University General Hospital (Athens, Greece), only one was positive for and one was positive for . Both isolates were extended-spectrum β-lactamase-negative, metallo-β-lactamase-positive and carried the gene. Neither of the isolates had mutations in and or carried or . The isolate also harboured on the same transferable plasmid with . This is the first report of a -positive and -positive harbouring a concurrent gene.

Mots clés: Fluoroquinolones; Metallo-β-lactamase; CMY-13

I. Galani, M. Souli, N. Mitchell, Z. Chryssouli, H. Giamarellou. Presence of plasmid-mediated quinolone resistance in isolates possessing in Greece. International Journal of Antimicrobial Agents, 2010, 36 (3), pp.252. ⟨10.1016/j.ijantimicag.2010.05.004⟩. ⟨hal-00608989⟩