Caenorhabditis elegans, a pluricellular model organism to screen new genes involved in mitochondrial genome maintenance

Matthew Glover Addo (1, 2) , Raynald Cossard (1) , Damien Pichard (1) , Kwasi Obiri-Danso (2) , Agnès Rötig (3) , Agnès Delahodde (1)

1 IMRB - Institut Mondor de Recherche Biomédicale
2 Department of Theoretical and Applied Biology
3 UPD5 - Université Paris Descartes - Paris 5

The inheritance of functional mitochondria depends on faithful replication and transmission of mitochondrial DNA (mtDNA). A large and heterogeneous group of human disorders is associated with mitochondrial genome quantitative and qualitative anomalies. Several nuclear genes have been shown to account for these severe OXPHOS disorders. However, in several cases the disease-causing mutations still remain unknown.

Mots clés: mitochondria; mtDNA maintenance; nematode

Domaines: Génomique, Transcriptomique et Protéomique [q-bio.GN]

Matthew Glover Addo, Raynald Cossard, Damien Pichard, Kwasi Obiri-Danso, Agnès Rötig, et al.. Caenorhabditis elegans, a pluricellular model organism to screen new genes involved in mitochondrial genome maintenance. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2010, 1802 (9), pp.765. ⟨10.1016/j.bbadis.2010.05.007⟩. ⟨hal-00608981⟩