Hospitalization of and mortality from bleeding peptic ulcer in Sweden. A nation-wide time-trend analysis.

Kristina Åhsberg (1) , Weimin Ye (2) , Yunxia Lu (2) , Zongli Zheng (2) , Christer Staël von Holstein (3)

1 Department of Surgery
2 MEB - Department of Medical Epidemiology and Biostatistics
3 Department of Surgery

Background and aims: Time-trend analyses of incidence and mortality in bleeding peptic ulcer show divergent results. This study is a detailed national analysis of hospitalization of and mortality from bleeding peptic ulcer in Sweden. Method: Data from all hospitalizations at departments with primary responsibility for patients with bleeding ulcer in Sweden, with main- or co-diagnosis of bleeding ulcer from 1987-2005 were retrieved from the Hospital Discharge Register. A validation study was performed due to an uncertainty in diagnostic setting after the introduction of ICD-10 in 1997. Annual hospitalization rates per 100 000 inhabitants in relation to gender, age and ulcer location was calculated as well as age-standardized 30-day mortality rates. Results: Hospitalizations for bleeding ulcer decreased from 63.9 to 35.3 per 100 000 inhabitants per year during the study period. The decrease was greater among men (men 80.4 to 40.9; women 47.7 to 29.7) and in younger age groups. Bleeding gastric ulcer decreased in both sexes and bleeding duodenal ulcer decreased most among men. Median age increased from 70 to 76 years. Standardized 30-day mortality increased from 5.3 to 6.2 per cent. The increased mortality was found in those over the age of 65 years and with duodenal ulcer disease, whereas mortality was unchanged in those with bleeding gastric ulcer. Conclusion: Hospitalization rates for bleeding peptic ulcer have markedly decreased in Sweden in all age groups. The 30-day mortality is low compared to other nationwide studies in the western world but has increased among patients with duodenal ulcer disease.

Mots clés: Medicine

Kristina Åhsberg, Weimin Ye, Yunxia Lu, Zongli Zheng, Christer Staël von Holstein. Hospitalization of and mortality from bleeding peptic ulcer in Sweden. A nation-wide time-trend analysis.. Alimentary Pharmacology and Therapeutics, 2011, 33 (5), pp.578. ⟨10.1111/j.1365-2036.2010.04562.x⟩. ⟨hal-00606302⟩