Characterisation of the proteome, diseases and evolution of the human postsynaptic density

Seth G.N. Grant (1) , Alex Bayes (1) , Louie N van de Lagemaat (1) , Mark O Collins (1) , Mike Dr Croning (1) , Ian R Whittle (1) , Jyoti S Choudhary (1)

1 Team 32 - Genes to Cognition

The postsynaptic density from human neocortex (hPSD) was isolated and 1461 proteins identified. hPSD mutations cause 133 neurological and psychiatric diseases and show enrichment in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong protein sequence conservation within mammalian lineages, particularly in hub proteins, indicates conserved function and organisation in primate and rodent models. The hPSD is a key structure for nervous system disease and behaviour.

Mots clés: Neurological Disorders; Psychiatric Disorders; Evolution; Proteomics

Seth G.N. Grant, Alex Bayes, Louie N van de Lagemaat, Mark O Collins, Mike Dr Croning, et al.. Characterisation of the proteome, diseases and evolution of the human postsynaptic density. Nature Neuroscience, 2010, ⟨10.1038/nn.2719⟩. ⟨hal-00601557⟩