Comparative in vitro activity of ceftobiprole against Gram-positive cocci

Carmen Betriu (1) , Esther Culebras (1) , María Gómez (1) , Fátima López-Fabal (1) , Iciar Rodríguez-Avial (1) , Juan J. Picazo (1)

1 Hospital Clínico San Carlos

The activity of ceftobiprole and comparator agents was evaluated against a collection of 880 isolates, comprising 200 meticillin-susceptible , 200 meticillin-resistant , 180 coagulase-negative staphylococci blood isolates, 100 and 200 macrolide-resistant β-haemolytic streptococci (100 and 100 ). Ceftobiprole showed excellent activity against staphylococci (minimum inhibitory concentrations ≤4μg/mL), irrespective of their susceptibility to other agents such as oxacillin, linezolid or glycopeptides. Ceftobiprole was also highly active against penicillin-resistant and macrolide-resistant β-haemolytic streptococci, inhibiting 99.6% of all streptococci tested at ≤0.5μg/mL. Based on these results, ceftobiprole appears to be a promising agent for the treatment of infections caused by multidrug-resistant Gram-positive pathogens.

Mots clés: Staphylococcus aureus; Coagulase-negative staphylococci; Streptococcus pneumoniae; Streptococcus pyogenes; Streptococcus agalactiae

Carmen Betriu, Esther Culebras, María Gómez, Fátima López-Fabal, Iciar Rodríguez-Avial, et al.. Comparative in vitro activity of ceftobiprole against Gram-positive cocci. International Journal of Antimicrobial Agents, 2010, 36 (2), pp.111. ⟨10.1016/j.ijantimicag.2010.04.003⟩. ⟨hal-00601193⟩