Association between multiple sclerosis and Candida species: evidence from a case-control study

J. Benito-León (1, 2) , D. Pisa (3) , R. Alonso (3) , P. Calleja (1) , M. Díaz-Sánchez (1) , L. Carrasco (3)

1 Department of Neurology
2 CIBERNED - Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas
3 CBMSO - Centro de Biología Molecular Severo Ochoa [Madrid]

Candida infection among multiple sclerosis (MS) patients has not been studied in depth. We determined whether there is an association between serological evidence of Candida infection and MS. Blood specimens were obtained from 80 MS patients and 240 matched controls. Immunofluorescence analysis and ELISA were used to detect Candida species antibodies and slot-blot to detect antigens. Using immunofluorescence analysis, moderate to high concentrations of serum antibodies to Candida famata were present in 30 (37.5%) MS patients vs. 30 (12.5%) controls ( < 0.001). Results for were 47.5% (38/80) in MS patients vs. 21.3% (51/240) in controls ( < 0.001), for 37% (28/80) vs. 17.1% (41/240) ( < 0.001) and for 46.3% (37/80) vs. 17.5% (42/240) ( < 0.001), respectively. After adjusting for age and gender, the odds ratios (95% confidence intervals) for MS, according to the presence of Candida antigens were: 2.8 (0.3-23.1,  = 0.337) for 1.5 (0.7-3.4,  = 0.290) for ; 7.3 (3.2-16.6,  < 0.001) for and 3.0 (1.5-6.1,  = 0.002) for . The results were similar after excluding ten patients on immunosuppressants. The results of this single study suggest that Candida species infection may be associated with increased odds of MS.

Mots clés: Life Sciences

J. Benito-León, D. Pisa, R. Alonso, P. Calleja, M. Díaz-Sánchez, et al.. Association between multiple sclerosis and Candida species: evidence from a case-control study. European Journal of Clinical Microbiology and Infectious Diseases, 2010, 29 (9), pp.1139-1145. ⟨10.1007/s10096-010-0979-y⟩. ⟨hal-00601187⟩