Relationship among pharmacokinetics and pharmacodynamics of fenretinide and plasma retinol reduction in neuroblastoma patients

Franca Formelli (1) , Elena Cavadini (1) , Roberto Luksch (2) , Alberto Garaventa (3) , Valentina Appierto (1) , Stefano Persiani (4)

1 Department of Experimental Oncology and Molecular Medicine
2 Operative Unit of Pediatrics
3 Department of Pediatric Hematology/Oncology
4 Department of Translational Sciences and Pharmacokinetics

Mots clés: Fenretinide; Retinol; Pharmacodynamics; Safety biomarker; Retinoids; Neuroblastoma

Franca Formelli, Elena Cavadini, Roberto Luksch, Alberto Garaventa, Valentina Appierto, et al.. Relationship among pharmacokinetics and pharmacodynamics of fenretinide and plasma retinol reduction in neuroblastoma patients. Cancer Chemotherapy and Pharmacology, 2010, 66 (5), pp.993-998. ⟨10.1007/s00280-010-1370-5⟩. ⟨hal-00598971⟩