Eye Movements in Amyotrophic Lateral Sclerosis and its Mimics: A Review with Illustrative Cases

Colette G Donaghy (1) , Matthew James Thurtell (2) , Erik P Pioro (3) , J Mark Gibson (1) , R John Leigh (4)

1 Royal Victoria Hospital, Belfast, N. Ireland
2 University Hospitals Case Medical Center
3 Section of ALS and Related Disorders, Neuromuscular Center
4 Case Western Reserve University [Cleveland]

Abnormal eye movements are increasingly recognized in patients with ALS and, when they occur, may provide insights into the pattern and pathogenesis of the disease process. In patients with disorders that mimic ALS, abnormal eye movements may point to the correct diagnosis. In both of these circumstances, systematic examination of eye movements and interpretation of the findings with reference to modern concepts of their neural substrate will aid diagnosis and suggest pathogenesis. Here, we highlight key points with illustrative case histories and eye movement records.

Mots clés: EYE MOVEMENTS; MOTOR NEURON DISEASE

Colette G Donaghy, Matthew James Thurtell, Erik P Pioro, J Mark Gibson, R John Leigh. Eye Movements in Amyotrophic Lateral Sclerosis and its Mimics: A Review with Illustrative Cases. Journal of Neurology, Neurosurgery and Psychiatry, 2010, 82 (1), pp.110. ⟨10.1136/jnnp.2010.212407⟩. ⟨hal-00594144⟩