Superinfection during treatment of nosocomial infections with tigecycline

E. García-Cabrera (1) , M. E. Jiménez-Mejías (2) , M. V. Gil Navarro (3) , M. J. Gómez-Gómez (4) , C. Ortiz-Leyba (5) , E. Cordero (2) , J. Pachón (2)

1 The Spanish Network for Research in Infectious Diseases
2 Infectious Diseases Service
3 Clinical Pharmacy Service
4 Microbiology Service
5 Intensive Care Service

We performed a retrospective and observational study of 51 patients treated with tigecycline, as the treatment for nosocomial infections due to multidrug-resistant microorganisms, to evaluate the superinfection rate and their etiologies. Superinfections were diagnosed in 12 (23.5%) patients (seven due to , 13.7%) and one patient had colonization. Five patients with superinfection died (41.6%), three due to superinfections and two to underlying diseases. The superinfection rate observed during tigecycline treatment is higher than that previously reported. is the most frequent agent, being the cause of 58.5% of all superinfections.

Mots clés: Life Sciences

E. García-Cabrera, M. E. Jiménez-Mejías, M. V. Gil Navarro, M. J. Gómez-Gómez, C. Ortiz-Leyba, et al.. Superinfection during treatment of nosocomial infections with tigecycline. European Journal of Clinical Microbiology and Infectious Diseases, 2010, 29 (7), pp.867-871. ⟨10.1007/s10096-010-0942-y⟩. ⟨hal-00593437⟩