Sleep disturbance and impulsive-compulsive behaviours in Parkinson's Disease

Sean S O'Sullivan (1) , Clare M Loane (2) , Andrew D Lawrence (3) , Andrew H Evans (4) , Paola Piccini (2) , Andrew J Lees (1)

1 Institute of Neurology
2 Respiratory Epidemiology and Public Health
3 Cardiff University
4 Department of Neurology, Royal Melbourne Hospital, Victoria

Objectives: Impulsive-compulsive behaviours (ICBs) in Parkinson's Disease (PD) have been anecdotally linked with disturbed sleep. We investigate measures of sleep in PD patients with and without ICBs, and in healthy controls. Methods: We compare Parkinsonian features, measures of depression, anxiety and mania, and sleep disturbance in 30 PD patients with ICBs (PD+ICB), 62 PD patients without ICBs (PD - ICB), and 48 healthy controls. Results: PD+ICB patients had younger age of PD onset, had taken more dopamine replacement therapy (DRT), had worse sleep, and elevated anxiety, depression and mania scores. Using multiple linear regression analyses, the total anxiety and depression scores, and presence of ICBs were the only variables associated with poorer sleep in PD. Conclusions: PD+ICB patients may show enhanced psychomotor responses to DRT that may in turn contribute to poor sleep quality. Sleep disturbance should be specifically enquired about in PD+ICB patients.

Mots clés: BEHAVIOURAL DISORDER; PARKINSON'S DISEASE; SLEEP DISORDERS

Sean S O'Sullivan, Clare M Loane, Andrew D Lawrence, Andrew H Evans, Paola Piccini, et al.. Sleep disturbance and impulsive-compulsive behaviours in Parkinson's Disease. Journal of Neurology, Neurosurgery and Psychiatry, 2010, 82 (6), pp.620. ⟨10.1136/jnnp.2009.186874⟩. ⟨hal-00591160⟩