Preserved pulmonary vasodilative properties of aerosolized Brain natriuretic peptide

Hanno H. Leuchte , Jens Michalek , Oezcan Soenmez , Tobias Meis , Gerald Bacher , Dorian Bevec , Jurgen Behr

Inhalation of vasoactive substances is an effective treatment of pulmonary hypertension. The B-type natriuretic peptide (BNP) leads to relaxation of smooth muscle cells, caused by an increased formation of cyclic guanosine monophosphate (cGMP). The biologic activity of BNP using an inhalative approach has not been addressed.

Mots clés: Isolated lung; Natriuretic peptides; pulmonary hypertension

Hanno H. Leuchte, Jens Michalek, Oezcan Soenmez, Tobias Meis, Gerald Bacher, et al.. Preserved pulmonary vasodilative properties of aerosolized Brain natriuretic peptide. Pulmonary Pharmacology & Therapeutics, 2009, 22 (6), pp.548. ⟨10.1016/j.pupt.2009.07.002⟩. ⟨hal-00589460⟩