Down-regulation of cough sensitivity after eucapnic dry air provocation in chronic idiopathic cough

Ewa-Lena Johansson , Ewa Ternesten-Hasséus , Eva Millqvist

Down-regulation of cough sensitivity in humans is rarely discussed in terms other than pharmacological treatment of cough or hypersensitive cough reflex. Chronic cough and increased cough sensitivity could be due to a number of airway and other diseases. When such conditions are excluded, there still remains a group of patients with no evident medical explanation for persistent coughing; such patients are often described as having "chronic idiopathic cough".

Mots clés: capsaicin; chemical sensitivity; dry air; cough; hyperventilation; sensory hyperreactivity; CI; CIC; EVH; FEV; NS; SHR; TRP channel; TRPV1; TRPM8

Ewa-Lena Johansson, Ewa Ternesten-Hasséus, Eva Millqvist. Down-regulation of cough sensitivity after eucapnic dry air provocation in chronic idiopathic cough. Pulmonary Pharmacology & Therapeutics, 2009, 22 (6), pp.543. ⟨10.1016/j.pupt.2009.07.001⟩. ⟨hal-00589459⟩