Deferasirox administration for the treatment of non-transfusional iron overload in patients with thalassaemia intermedia

Vassilios Ladis (1) , Helen Berdousi (1) , Efstathios Gotsis (2) , Antonis Kattamis (1)

1 First Department of Paediatrics, Athens University, Thalassaemia Unit
2 N/A

Abnormal iron regulation in patients with thalassaemia intermedia may lead to iron overload even in the absence of transfusions. There are limited data on iron chelator use in patients with thalassaemia intermedia and no guidelines exist for the management of iron overload. We present data from 11 patients with thalassaemia intermedia treated with deferasirox (Exjade®, 10-20 mg/kg/day) for 24 months. Liver iron concentration and serum ferritin levels significantly decreased over the first 12 months (P=0.005) and continued to decrease over the remainder of the study (P=0.005). This small-scale study indicates that deferasirox may be suitable for controlling iron levels in patients with thalassaemia intermedia.

Mots clés: Medicine

Vassilios Ladis, Helen Berdousi, Efstathios Gotsis, Antonis Kattamis. Deferasirox administration for the treatment of non-transfusional iron overload in patients with thalassaemia intermedia. British Journal of Haematology, 2010, 151 (5), pp.504. ⟨10.1111/j.1365-2141.2010.08346.x⟩. ⟨hal-00586594⟩