LSF/TFCP2c/LBP-1c is required for Snail1-induced Fibronectin gene expression

Montserrat Porta-De-La-Riva , Jelena Stanisavljevic , Josue Curto , Clara Francí , Víctor Manuel Díaz , Antonio García de Herreros , Josep Baulida (1)

1 IMIM-Hospital del Mar

Fibronectins are cell-secreted glycoproteins that modulate cell attachment, spreading, migration, morphology, differentiation and oncogenic transformation. Fibronectin expression is activated during epithelial-mesenchymal transition (EMT) and is a hallmark of mesenchymal cells. Results presented in this article reveal that a transcription factor previously unrelated with EMT, LSF/TFCP2c/LBP-1c, was translocated to the nucleus and bound to the Fibronectin promoter upon EMT induction by Snail1. Consequently, the interference of TFCP2c/LSF/LBP-1c activity prevented Fibronectin expression. Moreover, TFCP2c/LSF/LBP-1c was detected in nuclei of embryonic dermal mesenchymal cells adjacent to the hair bud, a cell population that expresses endogenous nuclear Snail1 and Fibronectin. Therefore, our data indicate a new molecular role for TFCP2c/LSF/LBP-1c in Fibronectin expression.

Mots clés: Life Sciences

Montserrat Porta-De-La-Riva, Jelena Stanisavljevic, Josue Curto, Clara Francí, Víctor Manuel Díaz, et al.. LSF/TFCP2c/LBP-1c is required for Snail1-induced Fibronectin gene expression. Biochemical Journal, 2011, 435 (3), pp.563-568. ⟨10.1042/BJ20102057⟩. ⟨hal-00586472⟩