A biomathematical model of human thrombopoiesis under chemotherapy

Markus Scholz (1) , Arnd Gross (1) , Markus Loeffler (1)

1 Institute for Medical Informatics

Intensification of cytotoxic chemotherapy enhances the outcome of several malignancies but is limited by haematotoxicity. While neutropenia and anaemia can be treated with supportive growth factor applications, thrombocytopenia remains a dose-limiting side effect due to the lack of clinically approved pharmaceutical growth factors. Hence, it is necessary to assess the degree of thrombocytopenia of newly designed intensified regimens in the planning phase of a clinical trial.

Mots clés: Thrombopheresis; Thrombopoietin; TPO

Markus Scholz, Arnd Gross, Markus Loeffler. A biomathematical model of human thrombopoiesis under chemotherapy. Journal of Theoretical Biology, 2010, 264 (2), pp.287. ⟨10.1016/j.jtbi.2009.12.032⟩. ⟨hal-00585789⟩